Covid-19 : the risk of booster shots

While doctors still advocate vaccination, including for 6-month-old babies, more and more scientists, including Jean-Marc Sabatier, are warning about the damage caused by repeated vaccinations on the immune system and the body.

The undesirable effects of vaccines against Covid-19 are not yet clearly listed by the WHO and by the health authorities. They are even sometimes denied. So much so that the European Medicines Agency (EMA) and also the French health authorities still recommend vaccination, including for 6-month-old babies, and even booster doses, the third and fourth, for the most fragile patients.
However, more and more scientists are warning against repeated vaccinations. In April 2022, the medical journal Cureus, admitted that “the adverse event profile of these vaccines has not been well established. Neurological complications are increasingly being reported. One of these identified complications is immune-mediated inflammatory polyneuropathy, which affects peripheral nerves and neurons.” Chronic inflammatory demyelinating polyneuropathy is a condition anticipated (by Jean-Marc Sabatier and colleagues) to be a Covid-19 disease, as it results from RAS dysfunction. This pathology was mentioned in the article published in April 2020 while no link with SARS-CoV-2 and Covid-19 had been described at this early period of the pandemic. In other words, repeated vaccinations, have a deleterious effect on the immune system and the body.

“A fundamental discovery”

“One of these adverse effects is immune-mediated inflammatory polyneuropathy,” the journal writes. It is further classified as acute or chronic based on the presentation and duration of symptoms.”
A few months later, the EMEA acknowledged that vaccine boosters could pose an immune response problem and called on individual states not to increase booster campaigns.
These recommendations come rather late. In April 2020, Jean-Marc Sabatier* published “a fundamental discovery” that he had made with virologists in Wuhan (China) a month earlier: “COVID-19-like diseases appear when a ubiquitous hormonal/physiological system in the human body, called the renin-angiotensin system (RAS), malfunctions, even in the absence of the SARS-CoV-2 virus”. published an interview with the scientist on December 21, 2020 entitled: “And if the RAS explained Covid?”. Or the story of a fundamental French discovery that could change the understanding and treatment of this decidedly mysterious disease.

The oil we put on the fire

jean-marc sabatier
Jean-Marc Sabatier (DR)

In this interview conducted by Dr. Jean-Michel Wendling, scientific advisor for, Jean-Marc Sabatier explains that “the real” culprit in Covid-19 is the renin-angiotensin system (RAS) and SARS-CoV-2 is the oil that is put on the fire. Indeed, so-called “Covid-19-like” diseases can occur, even in the absence of the virus, when the RAS has run amok and is working too hard.
As early as March 2020, Jean-Marc Sabatier had identified the extraordinary analogies between the consequences of an SARS-CoV-2 infection and those of a dysfunction of this “key” system of the human body. These analogies were reported in a scientific publication co-authored by Dr. Emmanuelle Faucon and her other collaborators, Prof. Zhijian Cao and Prof. Yingliang Wu, directors of the Wuhan Virology Laboratory (China).
Upon infection with SARS-CoV-2, the virus binds to the ACE2 (angiotensin converting enzyme 2) receptor of the target cells, which normally degrades the hormone angiotensin 2. This binding of SARS-CoV-2 to the ACE2 receptor prevents normal degradation of angiotensin 2, resulting in an increase in its concentration and overactivation of its cellular target, the AT1R receptor.

Everywhere in the human body

What is it? The overactivated AT1R receptor is very deleterious to the human body through the very harmful storm of released cytokines (TNF-alpha, interferon-gamma, interleukin-6, interleukin-1-beta, etc.). These mediators are responsible for the progression to the severe (even fatal) forms of Covid-19.
The renin-angiotensin system (RAS) is an essential hormonal/physiological system found throughout the human body, including the lungs, kidneys, spleen, liver, pancreas, intestines, heart, brain, testicles and prostate, uterus and ovaries, adrenal glands, auditory system, eyes, blood vessels, as well as cells of the “innate” immune system (circulating monocytes, macrophages, dendritic/antigen-presenting cells, granulocytes, mast cells, and natural killer cells). The RAS controls “innate” immunity (the “immediate” nonspecific response to pathogens) and the various microbiota (including the gut microbiota).

Covid-19 without virus?

The RAS is responsible for Covid-19 diseases via an overactivation of its “deleterious” receptor AT1R. This overactivated receptor induces mainly vasoconstriction/hypertension, inflammation, oxidative stress, hypoxia, angiogenesis, thrombogenesis, nitric oxide drop, hypertrophy and organ fibrosis.
This “deleterious” effect translates into the potential appearance of symptoms and diseases such as : high blood pressure, atherosclerosis, hypertrophy (heart, blood vessels), fibrosis (heart, lungs, kidneys, liver), heart failure, kidney and lung damage (including acute respiratory distress syndrome, and asthma), anosmia (loss of smell), agueusia (loss of taste), neurological disorders / memory impairment, diarrhea, intestinal and vascular inflammation, lipid metabolism dysfunction, obesity and glucose metabolism (diabetes), thrombosis / coagulopathy, skin and testicular damage. Furthermore, it appears that the “deregulated” RAS could be closely linked to the triggering of neurological disorders, cancers, and other autoimmune diseases (multiple sclerosis, rheumatoid arthritis, etc.), through its actions on the central nervous system, cell proliferation and adhesion, and “innate” immunity.
The in-depth knowledge of the physiological repercussions of a “runaway” RAS finally allows us to describe, understand and anticipate all the Covid-19 diseases associated with an SARS-CoV-2 infection.

The hope of vitamin D

How can this deleterious trend be stopped? Vitamin D is at the center of all hopes, as described by Jean-Marc Sabatier and Emmanuelle Faucon in March 2020. Covid-19 diseases (and symptoms) could be counteracted and treated by molecules capable of “braking” an overactivation of the RAS. Several known molecules are “brakes” of overactivated RAS (dexamethasone, melatonin, thymoquinone, sartans, enzyme conversion inhibitors, ivermectin, berbérine, quercetin, aliskiren, etc.). Among these molecules, vitamin D is particularly important because it is (in addition!) the fuel of all the cells of the immune system. These immune cells -like other cell types- require vitamin D (calcidiol or calcitriol) to act, especially against microbes like SARS-CoV-2. It can be easily administered orally and has a low cost. It is essential for people who are deficient or deficient in vitamin D (take cholecalciferol or vitamin D3, or even Dedrogyl (calcidiol) in case of emergency for an ultra-rapid action). Such a supplementation in vitamin D3 (or even vitamin D2) is recommended, particularly in this autumn period of active viral circulation, and considering the deficiency/ deficiency in vitamin D of the majority of the population.

*Jean-Marc Sabatier, Director of Research at the CNRS and Doctor in Cellular Biology and Microbiology, HDR in Biochemistry. Editor-in-Chief of the international scientific journals “Coronaviruses” and “Infectious Disorders – Drug Targets”. He speaks here in his own name.