An unexplored avenue for the treatment of Covid-19

Mast cell activation syndrome (MCAS) is an immunological condition caused by SARS-CoV-2 for which inexpensive treatments are available.

ccording to Jean-Marc Sabatier and his collaborators, the Covid-19 diseases induced by the SARS-CoV-2 virus result from the dysfunction of the renin-angiotensin system (RAS) via the overactivation of its receptor AT1R, as we have written several times. Recall that the RAS controls renal, pulmonary and cardiovascular autonomic functions as well as innate immunity and the gut and oral microbiota.

Symptoms and pathologies

In innate immunity, the cells involved are monocytes, macrophages, dendritic cells, granulocytes, mast cells and NK killer cells.
However, overactivation of the AT1R receptor leads to a macrophage activation syndrome (see diagram in the article below) which affects immune cells including B lymphocytes, T lymphocytes, neutrophils, NK cells, etc.
According to Jean-Marc Sabatier, SARS-CoV-2 infection also leads to mast cell activation syndrome (MCAS). This is a condition in which mast cells (cells of the innate immune system) excessively and inappropriately release numerous chemical “mediators” (histamine, heparin, cytokines, prostaglandins, TNF-Alpha, proteases, leukotrienes, including angiotensin converting enzyme 1 and RAS chymase, etc.), which cause various symptoms and pathologies.
These symptoms may be dermatological (hives, itching, bruising without apparent cause), cardiovascular (drop in blood pressure, dizziness, tachycardia, syncope), respiratory (cough, asthma, wheezing), gastrointestinal (nausea, vomiting, diarrhea or constipation), ophthalmologic (conjunctivitis), neurologic (memory loss, migraines, brain fog, mood swings, depression, aggressiveness), as well as anaphylactic shock (arterial hypotension associated or not with breathing difficulties).

Treatments exist

The causes of SAMA remain mysterious. However, there are potential treatments for this syndrome, including antihistamines (Cetirizine, Ketotifen, Famotidine) and anti-leukotrienes (Montelukast). Aspirin can also be used. There is also sodium cromoglycate, prepared in the pharmacy, as a mast cell stabilizer.
These are commonly used and inexpensive treatments. Thus, SAMA should be a preferred route of treatment for Covid-19 and Covid-long symptoms and pathologies.

It should be noted that SAMA can be triggered by vaccination, via the vaccine spike protein…

And this is how the SARS-CoV-2 virus causes Covid-19