Covid-19 : three years later, where are we?

Three years after the start of the SARS-CoV-2 pandemic, the virus is circulating at a low level in France and Europe. However, the side effects linked to vaccination are increasing. Explanations with Jean-Marc Sabatier*, PhD in Cellular Biology and Microbiology.

njection of a vaccine - credit freepik
njection of a vaccine – credit freepik

In March 2020, you announced that the SARS-CoV-2 virus deregulates a ubiquitous physiological system, called the renin-angiotensin system (RAS), and that this system was responsible for Covid-19 diseases. Three years later, do you confirm your first analysis?

After three years of this pandemic, the various research studies around the world fully confirm the atypical mode of action of the SARS-CoV-2 virus that we described in early 2020. The various pathologies described in anticipation at the time have now been verified.

Which pathologies are involved?

The overactivated AT1R receptor of the renin-angiotensin system (RAS) is capable of multiple attacks on the various tissues and organs of the human body, through its pro-hypertensive, pro-inflammatory, pro-angiogenic, pro-thrombotic, pro-oxidant, pro-hypoxemic, pro-fibrosing, and pro-hypertrophying properties. In addition, it decreases nitric oxide involved in inflammatory, immune and memory phenomena.

The ACE2 receptor of the spike protein

These various adverse effects are related to the ubiquity of the cellular receptor ACE2 (angiotensin converting enzyme 2), a major target of the SARS-CoV-2 spike protein and of the vaccine spike protein. Indeed, the RAS receptor ECA2 is present on many cell types (epithelial cells, endothelial cells, nerve cells, immune system cells, etc.) and explains the various pathologies of Covid-19 due to the overactivation of the AT1R receptor (also belonging to RAS). Among these pathologies are diabetes, dyslipidemia, autoimmune diseases, cancers, dermatitis, ocular and auditory disorders, cardiac disorders, various inflammatory diseases (vasculitis, conjunctivitis, uveitis, encephalitis, hepatitis, pancreatitis, thyroiditis, myocarditis, pericarditis, damage to reproductive organs, etc.), and neurological disorders

The consequences of vaccination

Today, three years after the beginning of the pandemic, while the virus seems to be in strong regression, especially in France, the side effects are strongly increasing. How do you explain this?

These are the joint consequences of the viral infection and the vaccination. The ability of a certain proportion of the vaccine spike protein (produced by the mRNA vaccines mainly used in the world) to bind to the ACE2 receptor, as the virus does, and the multiple vaccine boosters, explain this increase in Covid pathologies. There are, notably in France, more than two million people suffering from post-Covid or post-vaccination sequelae (17 million in Europe): increase in miscarriages, cardiovascular disorders, neurological disorders, digestive disorders, sexual disorders…
The importance of the RAS at the level of male and female reproductive organs (spermatogenesis, oocyte maturation, production of sex hormones, and its key role in the development of the fetus), provide scientific answers to these pathologies related to fertility.

So these vaccines have not fulfilled their objectives?

These vaccines, which do not prevent the infection of individuals, nor the inter-individual transmission of SARS-CoV-2, show three years later their limits and their potentially “deleterious” effects on the human organism. Thus, the benefit-risk ratio so highly praised at the beginning of the vaccination, turns out to be very unfavorable today. The damage already observed is probably only the tip of the iceberg. Let us hope that the worst is not yet to come…
Who is -and who will be- responsible for this?

jean-marc sabatier
Jean-Marc Sabatier (DR)

*Jean-Marc Sabatier is Director of Research at the CNRS and holds a PhD in Cell Biology and Microbiology and an HDR in Biochemistry. Editor-in-Chief of the international scientific journals: “Coronaviruses” and “Infectious Disorders – Drug Targets”. He is speaking in his own name.

Covid : collection of Jean-Marc Sabatier’s censored articles in English and Spanish